Andrea Curtabbi

Jan 13, 2025 | nature.com | Beatriz Cicuéndez |Juan Lopez |Juan López |Andrea Curtabbi |Javier Perez-Garcia |Daniel Jimenez-Blasco | +15 more

AbstractObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.