Andrea Farrell

1 month ago | science.org | Nicole Carter |Ke Wang |Benjamin Klein |Andrea Farrell

Editor’s summaryRegulatory T cells (Tregs) play an important role during homeostasis and are enriched in the liver in obesity-induced liver disease. Wang et al. explore how functional specification of liver Tregs is transcriptionally regulated in Western diet–induced obese mice. Effector Tregs expressing the transcription factor ATF4 accumulated in the livers of obese mice and promoted obesity-related liver fibrosis through integrin αvβ8–mediated activation of transforming growth factor–β.