Andrew Clark

Sep 11, 2023 | journals.plos.org | Amanda Lea |Andrew Clark |Andrew Dahl |Orrin Devinsky

Payoffs for NCD prevention and treatmentTesting the degree to which GxE interactions arise from evolutionary mismatch would answer mechanistic questions about how GxE interactions manifest. For example, are loci that were involved in adaptation to a population’s past environment more likely to exhibit GxE effects when the environment shifts? To what degree does the nature of GxE interactions vary across ancestries with distinct evolutionary histories?