Andrew Dahl

Nov 29, 2023 | nature.com | Clare Palmer |Morten Krebs |Vivek Appadurai |Esben Agerbo |Anders D. Børglum |David M. Hougaard | +7 more

AbstractAttention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals. First, we identify one genome-wide significant locus by comparing cases with ADHD and autism spectrum disorder (ASD) to cases with ADHD but not ASD.

Nov 20, 2023 | nature.com | Andrew Dahl |Ulzee An |Morten Krebs |Vivek Appadurai |Silviu-Alin Bacanu |Thomas Werge | +3 more

AbstractBiobanks often contain several phenotypes relevant to diseases such as major depressive disorder (MDD), with partly distinct genetic architectures. Researchers face complex tradeoffs between shallow (large sample size, low specificity/sensitivity) and deep (small sample size, high specificity/sensitivity) phenotypes, and the optimal choices are often unclear. Here we propose to integrate these phenotypes to combine the benefits of each.

Sep 11, 2023 | journals.plos.org | Amanda Lea |Andrew Clark |Andrew Dahl |Orrin Devinsky

Payoffs for NCD prevention and treatmentTesting the degree to which GxE interactions arise from evolutionary mismatch would answer mechanistic questions about how GxE interactions manifest. For example, are loci that were involved in adaptation to a population’s past environment more likely to exhibit GxE effects when the environment shifts? To what degree does the nature of GxE interactions vary across ancestries with distinct evolutionary histories?