Andrew Lloyd

Jan 2, 2025 | journalofinfection.com | Samaneh Moallemi |Nicodemus Tedla |Chathurani Sigera |Praveen Weeratunga |Deepika Fernando |Senaka Rajapakse | +2 more

KeywordsDengueplasma leakagebiomarkersevereResearch in ContextEvidence before this study:Plasma leakage is a key pathophysiological feature in dengue fever which characterises a subgroup of patients that can progress to life threatening severe disease. Thus, identifying biomarkers that can predict the likelihood of plasma leakage can help to triage patients for hospital admission in early infection.

Aug 23, 2024 | onlinelibrary.wiley.com | Andrew Lloyd |Anthony K. Redmond |Federica Giangrazi |Dafne Buffa

1 Introduction IL-17 family members—IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (or IL-25) and IL-17F—are potent pro-inflammatory immune mediators that are active as dimers [1, 2]. The IL-17A/F dimer regulates mucosal immune activity through neutrophil recruitment and secretion of matrix metalloproteases, which drive tissue repair [3, 4]. IL-17A/F also manipulates local microbiomes through the induction of antimicrobial peptide secretion by epithelial cells located at mucosal barriers [5].

May 20, 2024 | nph.onlinelibrary.wiley.com | Dylan Phillips |Andrew Lloyd

The existence of wheat, and other polyploid species, remains something of a conundrum. The generation of new synthetic polypoids is rarely a success, with most surviving only a few generations. Many hurdles lay in the path of such neopolyploids, with successful meiosis being the most challenging. Complex polyploids, such as bread wheat, must ensure a diploid-like behaviour of their homologous chromosome pairs during meiosis to generate viable gametes.

Apr 26, 2024 | bsa.org.uk | Andrew Lloyd

By Andrew Lloyd, Chief Customer Officer UK, PEXA Introducing Synchronised Real-Time Settlements The Real-Time Gross Settlement (RTGS) system is the Bank of England’s mechanism that enables building societies and other financial institutions to settle money at the central bank owed to one another from the various UK payment systems such as Faster Payments, Bacs, Mastercard and Visa.

Oct 26, 2023 | nature.com | Lucas Magalhães |Marco J Herold |Sandra Koit |Sainan Wang |Andrew Lloyd

AbstractArthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery identified the four-and-a-half-LIM domain protein 1 splice variant A (FHL1A) as a crucial host factor interacting with the hypervariable domain (HVD) of chikungunya virus (CHIKV) nonstructural protein 3 (nsP3). Here, we show that acute and chronic chikungunya disease in humans correlates with elevated levels of FHL1.