Federica Giangrazi

Aug 23, 2024 | onlinelibrary.wiley.com | Andrew Lloyd |Anthony K. Redmond |Federica Giangrazi |Dafne Buffa

1 Introduction IL-17 family members—IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (or IL-25) and IL-17F—are potent pro-inflammatory immune mediators that are active as dimers [1, 2]. The IL-17A/F dimer regulates mucosal immune activity through neutrophil recruitment and secretion of matrix metalloproteases, which drive tissue repair [3, 4]. IL-17A/F also manipulates local microbiomes through the induction of antimicrobial peptide secretion by epithelial cells located at mucosal barriers [5].