Andrew Schmidt

May 21, 2024 | nature.com | Shuai Tan |Colin Bergstrom |Gonçalo Vale |Jeffrey McDonald |Andrew Schmidt |Nguyen Vo | +4 more

AbstractNutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs. Here we show that colonic EEC deficiency leads to hyperphagia and obesity.