Colin Bergstrom

Jan 8, 2025 | nature.com | Jinxi Xiang |Xiyue Wang |Colin Bergstrom |Kun-Hsing Yu |Jeffrey J. Nirschl |Joel W Neal | +1 more

AbstractClinical decision-making is driven by multimodal data, including clinical notes and pathological characteristics. Artificial intelligence approaches that can effectively integrate multimodal data hold significant promise in advancing clinical care1,2. However, the scarcity of well-annotated multimodal datasets in clinical settings has hindered the development of useful models.

May 21, 2024 | nature.com | Shuai Tan |Colin Bergstrom |Gonçalo Vale |Jeffrey McDonald |Andrew Schmidt |Nguyen Vo | +4 more

AbstractNutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs. Here we show that colonic EEC deficiency leads to hyperphagia and obesity.