Angela L. Duker

Apr 30, 2024 | nature.com | Angela L. Duker |Jingjing Li |Ricki Carroll |Sarah M. Nikkel

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-41651-6, published online 3 November 2023In this article, the author name Alison J. Eaton was incorrectly written as Alison L. Eaton. The original article has been corrected.

Nov 3, 2023 | nature.com | Angela L. Duker |Jingjing Li |Ricki Carroll |Sarah M. Nikkel

AbstractMatrix Gla protein (MGP) is a vitamin K-dependent post-translationally modified protein, highly expressed in vascular and cartilaginous tissues. It is a potent inhibitor of extracellular matrix mineralization. Biallelic loss-of-function variants in the MGP gene cause Keutel syndrome, an autosomal recessive disorder characterized by widespread calcification of various cartilaginous tissues and skeletal and vascular anomalies.