Angela Mammana

Sep 11, 2024 | alz-journals.onlinelibrary.wiley.com | Alexa Pichet Binette |Angela Mammana |Laura E.M. Wisse |Marcello Rossi

1 INTRODUCTION Aggregates of misfolded alpha-synuclein (α-synuclein) proteins result in the formation of Lewy bodies and Lewy neurites in the brain.1 Lewy bodies and neurites are the core pathology of neuronal α-synuclein disease (i.e., Parkinson's disease [PD] and dementia with Lewy bodies [DLB]).2 They co-occur frequently with Alzheimer's disease (AD) pathology in brain tissue from patients with the clinical diagnosis of either AD dementia3-5 or neuronal α-synuclein disease.6, 7 Further,...

Sep 11, 2024 | alz-journals.onlinelibrary.wiley.com | Alexa Pichet Binette |Angela Mammana |Laura E.M. Wisse |Marcello Rossi

1 INTRODUCTION Aggregates of misfolded alpha-synuclein (α-synuclein) proteins result in the formation of Lewy bodies and Lewy neurites in the brain.1 Lewy bodies and neurites are the core pathology of neuronal α-synuclein disease (i.e., Parkinson's disease [PD] and dementia with Lewy bodies [DLB]).2 They co-occur frequently with Alzheimer's disease (AD) pathology in brain tissue from patients with the clinical diagnosis of either AD dementia3-5 or neuronal α-synuclein disease.6, 7 Further,...