Alexa Pichet Binette

1 month ago | jamanetwork.com | Gillian Coughlan |Hannah Klinger |Rory Boyle |Alexa Pichet Binette

Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis Key PointsQuestion  Is sex associated with rate of regional tau accumulation in adults without cognitive impairment at baseline? Findings  This meta-analysis of 6 tau positron emission tomography studies examined sex differences in tau accumulation over a mean of 2.8 years among 1376 individuals without cognitive impairment with baseline β amyloid (Aβ) measures.

Sep 11, 2024 | alz-journals.onlinelibrary.wiley.com | Alexa Pichet Binette |Angela Mammana |Laura E.M. Wisse |Marcello Rossi

1 INTRODUCTION Aggregates of misfolded alpha-synuclein (α-synuclein) proteins result in the formation of Lewy bodies and Lewy neurites in the brain.1 Lewy bodies and neurites are the core pathology of neuronal α-synuclein disease (i.e., Parkinson's disease [PD] and dementia with Lewy bodies [DLB]).2 They co-occur frequently with Alzheimer's disease (AD) pathology in brain tissue from patients with the clinical diagnosis of either AD dementia3-5 or neuronal α-synuclein disease.6, 7 Further,...

Sep 11, 2024 | alz-journals.onlinelibrary.wiley.com | Alexa Pichet Binette |Angela Mammana |Laura E.M. Wisse |Marcello Rossi

1 INTRODUCTION Aggregates of misfolded alpha-synuclein (α-synuclein) proteins result in the formation of Lewy bodies and Lewy neurites in the brain.1 Lewy bodies and neurites are the core pathology of neuronal α-synuclein disease (i.e., Parkinson's disease [PD] and dementia with Lewy bodies [DLB]).2 They co-occur frequently with Alzheimer's disease (AD) pathology in brain tissue from patients with the clinical diagnosis of either AD dementia3-5 or neuronal α-synuclein disease.6, 7 Further,...

Jun 13, 2024 | medrxiv.org | Rik Ossenkoppele |Gemma Salvadó |Shorena Janelidze |Alexa Pichet Binette

R.O. has received research support from Avid Radiopharmaceuticals, Janssen Research & Development, Roche, Quanterix and Optina Diagnostics. He has given lectures in symposia sponsored by GE Healthcare and serves on advisory boards for Asceneuron and Bristol Myers Squibb. SP has acquired research support (for the institution) from ki elements / ADDF and Avid. In the past 2 years, he has received consultancy/speaker fees from Bioartic, Biogen, Esai, Lilly, and Roche.