Anjali Yennemadi

1 month ago | biorxiv.org | Kevin Brown |Aaron Walsh |Anjali Yennemadi |Dearbhla M. Murphy

AbstractTuberculosis (TB)-associated mortality remains disproportionately high among people living with HIV (PLWH), with macrophage dysfunction representing a key mechanism of impaired host defence against Mycobacterium tuberculosis (Mtb) infection. Using the U1 chronically HIV-infected macrophage cell line model coupled with primary human monocyte-derived macrophages (MDMs) exposed to HIV-1 gp120, we systematically characterized immunometabolic perturbations during Mtb infection.