Kevin Brown

2 weeks ago | biorxiv.org | Kevin Brown |Jun Zhong |Adriana Miranda |Mengyan Zhang

AbstractTesticular germ cell tumors (TGCTs) are the most common malignancy in young men, exhibit a unique developmental origin and exceptional chemosensitivity. However, the molecular distinctions between TGCT subtypes remain poorly understood. Here we present a comprehensive genomic analysis of 252 treatment-naive primary TGCTs, integrating deep whole-genome sequencing with matched transcriptomic and epigenomic data.

1 month ago | biorxiv.org | Kevin Brown |Aaron Walsh |Anjali Yennemadi |Dearbhla M. Murphy

AbstractTuberculosis (TB)-associated mortality remains disproportionately high among people living with HIV (PLWH), with macrophage dysfunction representing a key mechanism of impaired host defence against Mycobacterium tuberculosis (Mtb) infection. Using the U1 chronically HIV-infected macrophage cell line model coupled with primary human monocyte-derived macrophages (MDMs) exposed to HIV-1 gp120, we systematically characterized immunometabolic perturbations during Mtb infection.

Jan 7, 2025 | flipboard.com | Kevin Brown

That Bryson DeChambeau is close to Donald Trump is not news anymore. But how deep their unlikely friendship is, has become a matter of speculation. …

Dec 18, 2024 | bmcgenomics.biomedcentral.com | Min Hyung Ryu |Jeong Yun |Kangjin Kim |Michele Gentili |Auyon J Ghosh |Frank C. Sciurba | +10 more

465 subjects met the case criteria for COPD, 213 subjects met the case criteria for IPF, and 348 subjects met the control criteria. Demographic and clinical characteristics of the 1,026 subjects included in our analysis are shown in Table 1. Notably, IPF subjects were predominantly male (70%). The cohort included 90% of self-identified white subjects. COPD subjects were predominantly smokers (95.2% have ever smoked) and IPF and control subjects were 65.3% and 67.8% ever smokers, respectively.

Feb 13, 2024 | mdpi.com | Ashish Vaswani |Kevin Brown |Yuan Jiang |Armando Alcázar Magaña

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