Anlan Yang

Jan 5, 2024 | nature.com | Anlan Yang |Shengjie Liu |Yilong Zou |Jianping Wu

AbstractPalmitoylation of cysteine residues at the C-terminal hypervariable regions in human HRAS and NRAS, which is necessary for RAS signaling, is catalyzed by the acyltransferase DHHC9 in complex with its accessory protein GCP16. The molecular basis for the acyltransferase activity and the regulation of DHHC9 by GCP16 is not clear.