Jianping Wu

Jan 15, 2025 | nature.com | Zhiqing Li |Jing Zhong |Yan Zhang |Jing Huang |Ying Zhen |Zhao Zhang | +1 more

AbstractArgonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression1. By contrast, PIWI-clade proteins predominantly function during gametogenesis to suppress transposons and ensure fertility1,2. Both clades use nucleic acid guides for target recognition by means of base pairing, crucial for initiating target silencing, often through direct cleavage.

Jan 12, 2025 | mdpi.com | Guoyin Liu |Jianping Wu |Yongqiang Wang |Yuansheng Xu

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Jan 9, 2025 | mdpi.com | Zhongbing Chang |Xin Xiong |Shuo Zhang |Jianping Wu

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Nov 10, 2024 | nature.com | Jianping Wu |Georg Kislinger |Benedikt Wefers |Wolfgang Wurst |Christian Behrends |Martina Schifferer | +2 more

AbstractOligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts of newly synthesized lipids. Yet, a complete understanding of this process remains elusive.

Nov 6, 2024 | mdpi.com | Jianping Wu |Lifeng Chen |Siyuan Fang |Chunming Wu

1. IntroductionAPIs, as crucial channels for functional invocations and data flows between applications, have significantly facilitated digital development, with their numbers experiencing exponential growth in recent years. However, due to their openness, APIs have increasingly become a prime target for abuse and hacking attacks, leading to many data breaches.