Anna R. Jussila

Sep 17, 2024 | nature.com | Nancy Li |Weiruo Zhang |Daniel Haensel |Anna R. Jussila |Cory Pan

AbstractCancer-associated inflammation is a double-edged sword possessing both pro- and anti-tumor properties through ill-defined tumor-immune dynamics. While we previously identified a carcinoma tumor-intrinsic resistance pathway, basal-to-squamous cell carcinoma transition, here, employing a multipronged single-cell and spatial-omics approach, we identify an inflammation and therapy-enriched tumor state we term basal-to-inflammatory transition.

May 10, 2023 | nature.com | Daniel Haensel |Bence Daniel |Tania Fabo |Jeremy Bjelajac |Nancy Li |Ansuman T. Satpathy | +2 more

AbstractCancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin, assembly, and dynamics of heterogeneous tumor immune niches. Here, we use single-cell and imaging-based spatial analysis to elucidate three microenvironmental neighborhoods surrounding the heterogeneous basal cell carcinoma tumor epithelia.