Anna R. Jussila

Sep 17, 2024 | nature.com | Nancy Li |Weiruo Zhang |Daniel Haensel |Anna R. Jussila |Cory Pan

AbstractCancer-associated inflammation is a double-edged sword possessing both pro- and anti-tumor properties through ill-defined tumor-immune dynamics. While we previously identified a carcinoma tumor-intrinsic resistance pathway, basal-to-squamous cell carcinoma transition, here, employing a multipronged single-cell and spatial-omics approach, we identify an inflammation and therapy-enriched tumor state we term basal-to-inflammatory transition.