Weiruo Zhang

Sep 17, 2024 | nature.com | Nancy Li |Weiruo Zhang |Daniel Haensel |Anna R. Jussila |Cory Pan

AbstractCancer-associated inflammation is a double-edged sword possessing both pro- and anti-tumor properties through ill-defined tumor-immune dynamics. While we previously identified a carcinoma tumor-intrinsic resistance pathway, basal-to-squamous cell carcinoma transition, here, employing a multipronged single-cell and spatial-omics approach, we identify an inflammation and therapy-enriched tumor state we term basal-to-inflammatory transition.

Jul 19, 2023 | nature.com | John Hickey |Winston R. Becker |Chenchen Zhu |Derek Chen |Daniel Cotter |Annika K Weimer | +10 more

AbstractThe intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with microbiota and affects overall health1. The intesting has a length of over nine metres, along which there are differences in structure and function2. The localization of individual cell types, cell type development trajectories and detailed cell transcriptional programs probably drive these differences in function.