Anna Scasny

1 month ago | biorxiv.org | Anna Scasny |Babek Alibayov |Ngoc Hoang |Ana Vidal

AbstractStreptococcus pneumoniae (Spn) is a primary cause of pneumonia, induces acute lung parenchymal infection, damaging through a unique metabolic pathway that generates hydrogen peroxide (H₂O₂) as a byproduct. This study reveals that Spn-derived H₂O₂, primarily produced by pyruvate oxidase (SpxB), inhibits the tricarboxylic acid (TCA) cycle in lung epithelial cells by targeting aconitase, glutamate dehydrogenase, and α-ketoglutarate dehydrogenase.