
Anna Scasny
Articles
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2 weeks ago |
biorxiv.org | Anna Scasny |Babek Alibayov |Ngoc Hoang |Ana Vidal
AbstractStreptococcus pneumoniae (Spn) is a primary cause of pneumonia, induces acute lung parenchymal infection, damaging through a unique metabolic pathway that generates hydrogen peroxide (H₂O₂) as a byproduct. This study reveals that Spn-derived H₂O₂, primarily produced by pyruvate oxidase (SpxB), inhibits the tricarboxylic acid (TCA) cycle in lung epithelial cells by targeting aconitase, glutamate dehydrogenase, and α-ketoglutarate dehydrogenase.
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