Anne Jackson

Sep 7, 2023 | nature.com | Alessia Faggian |Alessia David |Reedik Mägi |Emma Ahlqvist |Gudmar Thorleifsson |Robert Scott | +37 more

AbstractConventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations.

Aug 2, 2023 | nature.com | Yanick Hagemeijer |Albert Smith |Claudia Schurmann |Jennifer Brody |Gardar Sveinbjornsson |Cécile Lecoeur | +82 more

Method detailsPopulationsThe full RHR meta-analysis included 100 studies with data on RHR in up to 835,465 individuals. RHR was obtained from ECG in 54 studies, from pulse rate in 31 studies (of which seven were self-measured by the participants), from blood pressure monitor in nine studies, from electronic medical records in three studies, from manual measurement in one study and through a combination of multiple of the before mentioned methods in two studies.

Jun 8, 2023 | nature.com | Alice Williamson |Anne Jackson |Mette Andersen |Thomas Buchanan |Lee-Ming Chuang |Ren-Hua Chung | +43 more

Author notesThese authors jointly supervised this work: Karen L. Mohlke, Eleanor Wheeler, Stephen O’Rahilly, Daniel J. Fazakerley,Claudia Langenberg. Authors and AffiliationsMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UKAlice Williamson, Jian’an Luan, Nicholas J.