Emma Ahlqvist

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Articles

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification - Nature Genetics

Sep 7, 2023 | nature.com | Alessia Faggian |Alessia David |Reedik Mägi |Emma Ahlqvist |Gudmar Thorleifsson |Robert Scott | +37 more

AbstractConventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations.
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake - Nature Genetics

Jun 8, 2023 | nature.com | Alice Williamson |Anne Jackson |Mette Andersen |Thomas Buchanan |Lee-Ming Chuang |Ren-Hua Chung | +43 more

Author notesThese authors jointly supervised this work: Karen L. Mohlke, Eleanor Wheeler, Stephen O’Rahilly, Daniel J. Fazakerley,Claudia Langenberg. Authors and AffiliationsMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UKAlice Williamson, Jian’an Luan, Nicholas J.

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