Anne Laure Demessant

Sep 30, 2023 | onlinelibrary.wiley.com | Brigitte Dréno |Hilary E. Baldwin |Itaru Dekio |Anne Laure Demessant

Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: 1) altered sebum production, 2) inflammation, 3) excess keratinization, and 4) colonization with the commensal Cutibacterium acnes. However, the role of C. acnes has been unclear, since virtually all adults have C. acnes on their skin yet not all develop acne. In recent years, understanding of the role of C. acnes has expanded.