Brigitte Dréno

Sep 9, 2024 | onlinelibrary.wiley.com | Diala Haykal |Hugues Cartier |Brigitte Dréno

1 Introduction Human skin, as big as 2 m2, is the largest organ. The skin microbiome, consisting of a wide range of microorganisms, has a crucial function in preserving skin health and balance. The skin microbiome has been significantly transformed by recent progress in sequencing technologies, leading to a profound enhancement in our comprehension of its composition, diversity, and function [1, 2].

Sep 30, 2023 | onlinelibrary.wiley.com | Brigitte Dréno |Hilary E. Baldwin |Itaru Dekio |Anne Laure Demessant

Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: 1) altered sebum production, 2) inflammation, 3) excess keratinization, and 4) colonization with the commensal Cutibacterium acnes. However, the role of C. acnes has been unclear, since virtually all adults have C. acnes on their skin yet not all develop acne. In recent years, understanding of the role of C. acnes has expanded.