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Jan 9, 2025 | 
digitalcommons.library.tmc.edu | Caryn Bern |Eva Clark |Antonio L Teixeira |María P
KeywordsChagas disease, Chagas cardiomyopathy, Progression, SeverityAbstractChagas disease, the most common form of nonischaemic cardiomyopathy globally, is one of the leading causes of morbidity and mortality in Latin America. Chagas cardiomyopathy has a wide clinical spectrum and prognosis, which is primarily determined by the severity of left ventricular dysfunction. Chagas disease also affects the brain, particularly manifesting as cardioembolic strokes and cognitive impairments.
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Dec 4, 2024 | 
tandfonline.com | Izabela G. Barbosa |Aline Miranda |Michael Berk |Antonio L Teixeira
ABSTRACTIntroduction There is a growing body of evidence implicating gut-brain axis dysfunction in the pathophysiology of mood disorders. Accordingly, gut microbiota has become a promising target for the development of biomarkers and novel therapeutics for bipolar and depressive disorders. Areas covered We describe the observed changes in the gut microbiota of patients with mood disorders and discuss the available studies assessing microbiota-based strategies for their treatment.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Saulo Moreira |Antonio L Teixeira |Yasmin S Coimbra |Anne R Magalhães
Aim: In response to the coronavirus 2019 disease (COVID-19) pandemic, governments worldwide implemented measures to prevent infection, resulting in restricted school activities, restricted children’s freedom of movement, and increased risk of violence and injuries at home, including traumatic brain injury (TBI), among children. In Brazil, the consequences of the COVID-19 pandemic on the causes, severity, and mortality of pediatric TBI have not yet been investigated.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Pablo Cardozo |Júlia S. Fahel |Aline Miranda |Antonio L Teixeira
AbstractTNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with susceptibility to various pathogens that infect the central nervous system. Activation of both microglia and astrocytes leads to TNF-α production, which in turn triggers further activation of these cells.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Laís Martins |Antonio L Teixeira |ana m
BACKGROUND: A growing body of evidence has shown the involvement of the kynurenine pathway (KP), the primary route of tryptophan (TRP) catabolism, in the pathophysiology of neuropsychiatric disorders. OBJECTIVE: The study aims to provide a comprehensive and critical overview of the clinical evidence on the KP involvement in the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD), discussing therapeutic opportunities.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Antonio L Teixeira |António Manuel Teixeira |Antônio Lucio Teixeira |Henrique Noronha |Sarah Frusciante |Gianfranco Diretto
AbstractDespite current knowledge showing that fruits like tomato and grape berries accumulate different components of the light reactions and Calvin cycle, the role of green tissues in fruits is not yet fully understood. In mature tomato fruits, chlorophylls are degraded and replaced by carotenoids through the conversion of chloroplasts in chromoplasts, while in red grape berries, chloroplasts persist at maturity and chlorophylls are masked by anthocyanins.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Antonio L Teixeira
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Natalia Dias |Antonio L Teixeira |Breno S. Diniz |Érica L. Vieira
OBJECTIVE: This study aimed at investigating a set of peripheral cytokines in elderly female patients with MDD, comparing them to controls, and assessing the potential influence of clinical comorbidities on inflammatory markers. METHODS: Twenty-five elderly female patients diagnosed with MDD and 19 age-matched female controls were enrolled on this study.
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Oct 31, 2024 | 
digitalcommons.library.tmc.edu | Natalia Rocha |Natália P Rocha |Antonio L Teixeira |de Miranda |Danielle S Macedo
BACKGROUND: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and mortality worldwide. The pathophysiological mechanisms of neuropsychiatric disorders remain to be fully elucidated, which has hampered the development of effective therapies. The Renin Angiotensin System (RAS) is classically viewed as a key regulator of cardiovascular and renal homeostasis.
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Sep 20, 2024 | 
mdpi.com | Antonio L Teixeira |António José Teixeira |Antônio Lucio Teixeira |Pietro P. M |Peter E. Toorop
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