Ao Yuan

Jul 3, 2023 | onlinelibrary.wiley.com | Wenqing He |Grace Yi |Ao Yuan

1 INTRODUCTION Correlated survival data commonly arise from clinical trials, epidemiological studies, and cancer research. Examples include studies of survival times of family members with cancer, where the primary endpoint (e.g., death) and the secondary endpoint (e.g., time to tumour progression) are gathered for study subjects. Different models have been developed to describe various types of dependence of correlated survival times on covariates.

May 14, 2023 | frontiersin.org | Shuqi Wang |Ao Yuan |Ruzong Fan

1 IntroductionMany heritable traits are governed by a single DNA variant (single-nucleotide polymorphism, SNP) or a single gene, for example, cystic fibrosis (Tsui et al., 1985). Such disease variants can generally be detected in the course of a genome-wide association study (GWAS), where for one variant after another, genotype frequencies are compared between cases (affected by disease) and control individuals.