Ruzong Fan

May 14, 2023 | frontiersin.org | Shuqi Wang |Ao Yuan |Ruzong Fan

1 IntroductionMany heritable traits are governed by a single DNA variant (single-nucleotide polymorphism, SNP) or a single gene, for example, cystic fibrosis (Tsui et al., 1985). Such disease variants can generally be detected in the course of a genome-wide association study (GWAS), where for one variant after another, genotype frequencies are compared between cases (affected by disease) and control individuals.