Aristotle N. Voineskos

May 8, 2024 | psiquiatria.com | Aristotle N. Voineskos |Colin Hawco

La neuroimagen funcional, especialmente la resonancia magnética funcional (fMRI), ha sido fundamental para comprender la neurobiología de la esquizofrenia pero ha enfrentado desafíos en su aplicación clínica. Este artículo revisa críticamente el uso del fMRI en la investigación de la esquizofrenia, destacando su evolución desde estudios de activación cerebral hasta el uso de la conectividad global y algoritmos de aprendizaje automático para identificar marcadores predictivos.

Mar 18, 2024 | nature.com | Daniel M. Blumberger |Benoit H. Mulsant |Benoît Mulsant |Aristotle N. Voineskos |Tarek K. Rajji

AbstractWhether individuals with mild cognitive impairment (MCI) and a history of major depressive disorder (MDD) are at a higher risk for cognitive decline than those with MCI alone is still not clear. Previous work suggests that a reduction in prefrontal cortical theta phase-gamma amplitude coupling (TGC) is an early marker of cognitive impairment.

Aug 19, 2023 | nature.com | Tarek K. Rajji |Aristotle N. Voineskos

AbstractMost patients with late-life depression (LLD) have cognitive impairment, and at least one-third meet diagnostic criteria for mild cognitive impairment (MCI), a prodrome to Alzheimer’s dementia (AD) and other neurodegenerative diseases. However, the mechanisms linking LLD and MCI, and brain alterations underlying impaired cognition in LLD and LLD + MCI remain poorly understood.