Aritz Roa-Eguiara

Dec 11, 2024 | nature.com | Haidai Hu |Philipp F. Popp |Aritz Roa-Eguiara |Nicole R. Rutbeek |Leighton J Payne |Dorentina Humolli | +8 more

AbstractZorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems1,2.

Oct 28, 2024 | biorxiv.org | Victor Klein-Sousa |Aritz Roa-Eguiara |Claudia Sybille Kielkopf |Nicholas Sofos

AbstractBacteriophages use receptor-binding proteins (RBPs) to adhere to bacterial hosts. Understanding the structure of these RBPs can provide insights into their target interactions. Tail fibers, a prominent type of RBP, are typically elongated, flexible, and trimeric proteins, making it challenging to obtain high-resolution experimental data of their full-length structures.

Dec 18, 2023 | biorxiv.org | Haidai Hu |Thomas Hughes |Philipp F. Popp |Aritz Roa-Eguiara

AbstractZorya is a recently identified and widely distributed bacterial immune system, which protects against phage invasion. It consists of a predicted membrane-embedded complex (ZorAB) and soluble components that differ among Zorya subtypes, notably ZorC and ZorD, in type I Zorya systems. Here, we reveal the molecular basis of the Zorya defense system using cryo-electron microscopy, mutagenesis, fluorescence microscopy, proteomics, and functional studies.