Arizona Alzheimer’s Consortium

Mar 27, 2024 | academic.oup.com | Tim T |R Jarrett |Biomarker Laboratory |Arizona Alzheimer’s Consortium

Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI).

Feb 29, 2024 | academic.oup.com | Arizona Alzheimer’s Consortium |Min Kyung Chu |Deming Jiang

Frontotemporal Dementia (FTD) is a disease of high heterogeneity, apathy and disinhibition present in all subtypes of FTD and imposes a significant burden on families/society. Traditional neuroimaging analysis has limitations in elucidating the network localization due to individual clinical and neuroanatomical variability.

Oct 5, 2023 | alzres.biomedcentral.com | Mayo Clinic Arizona |Arizona Alzheimer’s Consortium

The DIAGNOSE CTE Research Project includes 120 former professional American football players (PRO), 60 former college football players (COL), and 60 same-age men without a history of playing football or other RHI exposure (i.e., unexposed [UE]). All participants were male and 45–74 years old. Three participants did not receive florbetapir PET due to dose failure at the manufacturer. Therefore, the sample for this study consisted of 237 men, including 119 PRO, 60 COL, and 58 asymptomatic UE.