Biomarker Laboratory

Oct 27, 2024 | onlinelibrary.wiley.com | John Mach |Matthew McKay |Biomarker Laboratory |Kevin Winardi

α-SMA alpha smooth muscle actin CI credible interval CYP cytochrome P450 DMET drug-metabolizing enzyme and transporter FC fold change FDR false discovery rate GO gene ontology GS gene significance GSEA gene set enrichment analysis H&E hematoxylin and eosin HCA hierarchical clustering analysis KEGG Kyoto encyclopedia of genes and genomes LC-MS/MS liquid chromatography-tandem mass spectrometry MGI GXD Mouse Genome Informatics Gene eXpression Database MHC Major histocompatibility complex MM...

Mar 27, 2024 | academic.oup.com | Tim T |R Jarrett |Biomarker Laboratory |Arizona Alzheimer’s Consortium

Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI).

Mar 22, 2024 | onlinelibrary.wiley.com | Sooin Byeon |Matthew McKay |Biomarker Laboratory |Mark Molloy

1 INTRODUCTION Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest survival rate of all major cancer and is projected to become the second common cause of cancer related death by 2030.1, 2 These dismal statistics are due to many factors, including shortcomings in current management of PDAC. Most PDAC patients have advanced disease at the time of diagnosis. Only 20% of the patients could be offered surgery, the only potentially curative-intent therapy.

Oct 13, 2023 | alzres.biomedcentral.com | von Arnim |Christine A. F |Biomarker Laboratory

Traditionally, AD diagnosis was based solely on clinical criteria; however, current guidelines for AD diagnosis also consider the presence of biologic markers. For the neuropathologic diagnosis of AD using biomarkers, the National Institute on Aging and Alzheimer's Association (NIA-AA) “ATN” research framework can be used [23].

Sep 28, 2023 | onlinelibrary.wiley.com | Biomarker Laboratory |M. Fujita |A. Vankayalapati |G. Wamwere-Njoroge

1 INTRODUCTION Infants require intensive care to thrive. Whereas a mother's role is centralized when considering their infant's needs, care is frequently provided by others as well. Alloparent care refers to childcare by an individual other than their mother (Hrdy, 2009; Waynforth, 2020; Wilson, 1975).