Arjun Nanda

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Direct transposition of native DNA for sensitive multimodal single-molecule sequencing - Nature Genetics

May 9, 2024 | nature.com | Arjun Nanda |Megan S. Ostrowski |Leanne C Sayles |Ansuman T. Satpathy |E. Alejandro Sweet-Cordero |Hani Goodarzi | +1 more

AbstractConcurrent readout of sequence and base modifications from long unamplified DNA templates by Pacific Biosciences of California (PacBio) single-molecule sequencing requires large amounts of input material. Here we adapt Tn5 transposition to introduce hairpin oligonucleotides and fragment (tagment) limiting quantities of DNA for generating PacBio-compatible circular molecules.

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