Hani Goodarzi

Oct 28, 2024 | nature.com | Hani Goodarzi

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-52215-7, published online 9 September 2024In this article, the affiliation ‘Arc Institute, Palo Alto, CA’ was missing for Shaopu Zhou and Hani Goodarzi. The original article has not been corrected.

Sep 14, 2024 | nature.com | William Connell |Kristle Garcia |Hani Goodarzi

AbstractChemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we develop ChemProbe, a model that predicts cellular sensitivity to hundreds of molecular probes and drugs by learning to combine transcriptomes and chemical structures.

Sep 14, 2024 | flipboard.com | William Connell |Kristle Garcia |Hani Goodarzi |Michael Keiser

Environment1 day agoGigantic Wave in Pacific Ocean Was The Most Extreme 'Rogue Wave' on RecordScienceAlert - Carly Cassella • 1dIn November of 2020, a freak wave came out of the blue, lifting a lonesome buoy off the coast of British Columbia 17.6 meters high (58 feet).

Jul 9, 2024 | biorxiv.org | Kate Crawford |Santiago Lopez |Hani Goodarzi

AbstractThe bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a template for the production of custom DNA sequences by reverse transcription.

May 9, 2024 | nature.com | Arjun Nanda |Megan S. Ostrowski |Leanne C Sayles |Ansuman T. Satpathy |E. Alejandro Sweet-Cordero |Hani Goodarzi | +1 more

AbstractConcurrent readout of sequence and base modifications from long unamplified DNA templates by Pacific Biosciences of California (PacBio) single-molecule sequencing requires large amounts of input material. Here we adapt Tn5 transposition to introduce hairpin oligonucleotides and fragment (tagment) limiting quantities of DNA for generating PacBio-compatible circular molecules.