Armaan A Abraham

Jul 10, 2024 | biorxiv.org | Zhixin Tan |Priyanka Shrestha |Armaan A Abraham |Emily R Bozich

AbstractSystems serology aims to broadly profile the antigen binding, Fc biophysical features, immune receptor engagement, and effector functions of antibodies. This experimental approach excels at identifying antibody functional features that are relevant to a particular disease. However, a crucial limitation of this approach is its incomplete description of what structural features of the antibodies are responsible for the observed immune receptor engagement and effector functions.