
Articles
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6 days ago |
onclive.com | Ashling Wahner
Pirtobrutinib (Jaypirca)—the first noncovalent BTK inhibitor approved for patients with chronic lymphocytic leukemia (CLL)—has reshaped third-line treatment strategies in this disease space and prompted new considerations regarding treatment sequencing and patient selection as the paradigm grows more complex, according to Nicole Lamanna, MD.
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1 week ago |
onclive.com | Ashling Wahner
Despite the lack of clinical benefit generated by immune checkpoint inhibitor (ICI) rechallenge for most patients with advanced renal cell carcinoma (RCC) who have progressed on prior immunotherapy, ongoing research is seeking to clarify the application of this strategy in select patient subgroups, according to Evan T. Hall, MD, MPhil, who added that increasingly tailored later-line RCC regimens are also of interest for this patient population.
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1 week ago |
onclive.com | Ashling Wahner
Treatment with SCG101, an autologous hepatitis B virus (HBV)–specific T-cell therapy, led to sustained HBV-DNA and serum hepatitis B surface antigen (HBsAg) clearance in patients with advanced HBV-related hepatocellular carcinoma (HCC), according to findings from a phase 1 trial (NCT06617000) presented at the 2025 European Association for the Study of the Liver Congress.1 All 17 patients with heavily pretreated HBV-related HCC who received a single infusion of SCG101 in the trial showed rapid...
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1 week ago |
onclive.com | Ashling Wahner
Evolving insights and maturing data from bladder cancer clinical trials, such as the phase 3 CheckMate 274 trial (NCT02632409) evaluating adjuvant nivolumab (Opdivo) in patients with muscle-invasive bladder cancer (MIBC), are prompting further considerations for adjuvant treatment strategies that may better personalize care and enable bladder preservation, according to Petros Grivas, MD, PhD.
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1 week ago |
onclive.com | Ashling Wahner
Practice-changing results with the addition of perioperative durvalumab (Imfinzi) to neoadjuvant chemotherapy have both refined the management of muscle-invasive bladder cancer (MIBC) and raised questions regarding the optimal comparator arms to use in future investigations of immunotherapy in this disease, according to Petros Grivas, MD, PhD.
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