Asim Bisoi

1 month ago | biorxiv.org | Trideep Majumdar |Asim Bisoi |Prashant Singh |Indian Association

AbstractIn this study, the effect of the chemical nature of the confinement on the folding and thermal stability of the telomere G-quadruplex (G4) has been investigated by studying the folding pattern of different telomere DNA sequences with varying numbers and arrangements of thymine loop nucleobases in the presence of anionic and cationic nanosized water pools. The findings suggest that both anionic and cationic water pools fold the telomere sequences into G4 of the same topology.

2 months ago | dx.doi.org | Asim Bisoi |Trideep Majumdar |Sunipa Sarkar |Prashant Singh

2 months ago | pubs.acs.org | Asim Bisoi |Trideep Majumdar |Sunipa Sarkar |Prashant Singh

Jan 14, 2025 | dx.doi.org | Asim Bisoi |Sunipa Sarkar |Prashant Singh |Trideep Majumdar

May 21, 2024 | biorxiv.org | Sunipa Sarkar |Akash Chatterjee |Subhojit Paul |Asim Bisoi

AbstractHydroxychloroquine (HCQ), and chloroquine (CQ) are in the preclinical trial stage for cancer along with their active application in autoimmune diseases and malaria. One of the critical hallmarks of cancer cells is the elevated expression of various oncogenes which promote cancer progression and contribute to poor prognosis. The upstream of the promoter region of these oncogenes often exhibits a G-quadruplex (G4) DNA structure which regulates the gene expression.