Subhojit Paul

May 21, 2024 | biorxiv.org | Sunipa Sarkar |Akash Chatterjee |Subhojit Paul |Asim Bisoi

AbstractHydroxychloroquine (HCQ), and chloroquine (CQ) are in the preclinical trial stage for cancer along with their active application in autoimmune diseases and malaria. One of the critical hallmarks of cancer cells is the elevated expression of various oncogenes which promote cancer progression and contribute to poor prognosis. The upstream of the promoter region of these oncogenes often exhibits a G-quadruplex (G4) DNA structure which regulates the gene expression.

Apr 19, 2024 | mdpi.com | Subhojit Paul |Tanmoy Mukherjee |Kaushik Das

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Dec 15, 2023 | dx.doi.org | Subhojit Paul |Gustavo Martinez |Sharmilee Sarkar |Kaushika Olymon

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Inf. Model. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Oct 6, 2023 | mdpi.com | Kaushik Das |Subhojit Paul |Arnab Ghosh |Saurabh Gupta

1. Introduction 1.1. Extracellular Vesicles: More Than Cellular DustExtracellular vesicles (EVs) were first identified in 1946 by Chargaff and West as platelet–derived procoagulant particles in plasma [1]. More than two decades later, Wolf renamed these procoagulant plasma–derived bodies “platelet dust” [2]. A further decade passed before the intriguing discovery of Harding et al.

Jul 29, 2023 | mdpi.com | Kaushik Das |Subhojit Paul |Tanmoy Mukherjee |Arnab Ghosh

Abstract:Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tissue functions. Inflammation is essential in the recruitment of immune cells at the site of infection, which not only aids in the elimination of the cause, but also initiates the healing process.