Audun Kvalvaag

Feb 27, 2024 | onlinelibrary.wiley.com | Michael L. Dustin |Audun Kvalvaag

INTRODUCTION T cell activation is initiated by TCR mediated recognition of cognate pMHC presented on the surface of APCs. This triggers a signaling cascade which leads to formation of the immunological synapse, a specialized junction through which T cells can directly pass and receive information to and from APCs.[1-3] This can be in the form of costimulatory or inhibitory signals relayed through protein-protein interactions on the surface of the T cells and the APCs,[4, 5] proteins and/or...