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Sep 17, 2024 | 
jci.org | Jesusa Capera |Michael L. Dustin |Garry Dolton |Pierre J. Rizkallah
AbstractMicrobial mimicry, the process in which a microbial antigen elicits an immune response and breaks tolerance to a structurally related self-antigen, has long been proposed as a mechanism in autoimmunity. In this issue of the JCI, Dolton et al. extend this paradigm by demonstrating that a naturally processed peptide from Klebsiella oxytoca acts as a superagonist for autoreactive T cells in type 1 diabetes (T1D).
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Aug 28, 2024 | 
nature.com | Ichitaro Abe |JING CHEN |Linna Zhou |Noelia Martínez-Sánchez |Michael L. Dustin |Cheng Zhan | +5 more
AbstractHuman mutations in neuropeptide Y (NPY) have been linked to high body mass index but not altered dietary patterns1. Here we uncover the mechanism by which NPY in sympathetic neurons2,3 protects from obesity.
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Aug 16, 2024 | 
nature.com | Falk Schneider |Pablo F. Céspedes |Michael L. Dustin
AbstractCells crucially rely on the interactions of biomolecules at their plasma membrane to maintain homeostasis. Yet, a methodology to systematically quantify biomolecular organisation, measuring diffusion dynamics and oligomerisation, represents an unmet need.
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Jun 10, 2024 | 
nature.com | Ewoud B. Compeer |Aristides G. Eliopoulos |Themis Alissafi |Michael L. Dustin
AbstractCancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in tumour progression. However, the mechanisms via which CAFs influence the anti-tumour immunity remain poorly understood. Here, using multiple tumour models and biopsies from cancer patients, we report that α-SMA+ CAFs can form immunological synapses with Foxp3+ regulatory T cells (Tregs) in tumours.
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Apr 24, 2024 | 
nature.com | Mike B. Barnkob |Yale Michaels |Philip Macklin |Uzi Gileadi |Salvatore Valvo |Margarida Rei | +14 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-47424-z, published online 12 April 2024In this article the title was incorrectly written as ‘Semmaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells’ but should have been ‘Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells’. The original article has been corrected.
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Apr 12, 2024 | 
nature.com | Yale Michaels |Philip Macklin |Uzi Gileadi |Salvatore Valvo |Margarida Rei |Corinna A. Kulicke | +14 more
AbstractSemaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely understood. Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 are upregulated on stimulated CD8+ T cells, allowing tumour-derived SEMA3A to inhibit T cell migration and assembly of the immunological synapse.
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Apr 1, 2024 | 
nature.com | Pablo F. Céspedes |Uzi Gileadi |Zhu Liang |Fei Gao |Nikolaos Kanellakis |Yi-Ling Chen | +7 more
AbstractCancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear.
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Feb 27, 2024 | 
onlinelibrary.wiley.com | Michael L. Dustin |Audun Kvalvaag
INTRODUCTION T cell activation is initiated by TCR mediated recognition of cognate pMHC presented on the surface of APCs. This triggers a signaling cascade which leads to formation of the immunological synapse, a specialized junction through which T cells can directly pass and receive information to and from APCs.[1-3] This can be in the form of costimulatory or inhibitory signals relayed through protein-protein interactions on the surface of the T cells and the APCs,[4, 5] proteins and/or...
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Nov 27, 2023 | 
pharmafocusasia.com | Cosima T. Baldari |Michael L. Dustin
Author(s) : Cosima T. Baldari, Michael L. DustinBook Description:This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse.
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Nov 6, 2023 | 
nature.com | Fanny Lafouresse |Michael L. Dustin |Salvatore Valitutti |Kévin Cortacero
AbstractAn unresolved issue in contemporary biomedicine is the overwhelming number and diversity of complex images that require annotation, analysis and interpretation. Recent advances in Deep Learning have revolutionized the field of computer vision, creating algorithms that compete with human experts in image segmentation tasks. However, these frameworks require large human-annotated datasets for training and the resulting “black box” models are difficult to interpret.
