Austin Hartman

Nov 8, 2024 | biorxiv.org | Oliver Takacsi-Nagy |Austin Hartman |Andy Chen |Yajie Yin

AbstractProtein-coding genes in the human genome evolved via modular rearrangement of domains from ancestral genes. Here, we develop a scalable, evolutionarily guided method to assemble novel protein-coding genes from constituent domains within a protein family, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.

Jan 12, 2024 | biorxiv.org | Austin Hartman |Rahul Satija

AbstractThe burgeoning interest in in situ multiplexed gene expression profiling technologies has opened new avenues for understanding cellular behavior and interactions. In this study, we present a comparative benchmark analysis of six in situ gene expression profiling methods, including both commercially available and academically developed methods, using publicly accessible mouse brain datasets.