Yajie Yin

Nov 8, 2024 | biorxiv.org | Oliver Takacsi-Nagy |Austin Hartman |Andy Chen |Yajie Yin

AbstractProtein-coding genes in the human genome evolved via modular rearrangement of domains from ancestral genes. Here, we develop a scalable, evolutionarily guided method to assemble novel protein-coding genes from constituent domains within a protein family, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.

Nov 8, 2023 | nature.com | Caleb A Lareau |Yajie Yin |Katie Maurer |Katalin Sandor |Bence Daniel |Jose Sanz Peña | +20 more

AbstractCell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a comprehensive understanding of the mechanisms of toxicities observed in patients receiving T cell therapies, including recent reports of encephalitis caused by reactivation of human herpesvirus 6 (HHV-6)1.

Apr 23, 2023 | biorxiv.org | Caleb A Lareau |Yajie Yin |Jacob Gutierrez |Ryan S. Dhindsa

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Apr 4, 2023 | opg.optica.org | Yajie Yin |Jiaxue Chen |Min Tang |Liuya Sun

AbstractWe purpose a novel portable 3D-printed umbrella photoacoustic (PA) cell, to the best of our knowledge, for trace gas detection. Its simulation and structural optimization were performed via finite element analysis using COMSOL software. We investigate the factors affecting the PA signals using both experimentation and theory. By measuring methane, a minimum detection limit of 5.36 ppm (signal-to-noise ratio, 223.8) with a lock-in time of 3s was achieved.

Mar 8, 2023 | nature.com | Won-Ju Kim |Caleb A Lareau |Elena Sotillo |Yajie Yin |Alexander Dunn |Ansuman T. Satpathy | +2 more

AbstractAlthough chimeric antigen receptor (CAR) T cells have altered the treatment landscape for B cell malignancies, the risk of on-target, off-tumour toxicity has hampered their development for solid tumours because most target antigens are shared with normal cells1,2. Researchers have attempted to apply Boolean-logic gating to CAR T cells to prevent toxicity3,4,5; however, a truly safe and effective logic-gated CAR has remained elusive6.