Austin Vogt

Nov 4, 2024 | jbc.org | Sarah Gardner |Philadelphia Pennsylvania |Austin Vogt |Trevor M Penning

IntroductionCholesterol is a key sterol that is an essential precursor of all steroid hormones and bile acids (1-3). Cholesterol biosynthesis is tightly regulated, and homeostasis is maintained through dynamic processes of export and esterification. One of the main fates of cholesterol is primary bile acid synthesis which is the predominant mechanism for clearance of excess cholesterol (4, 5).

Jul 24, 2024 | jbc.org | Austin Vogt |Mary R. Szurgot |Lauren Gardner |David Schultz

AbstractThe HIRA histone chaperone complex is comprised of four protein subunits: HIRA, UBN1, CABIN1, and transiently associated ASF1a. All four subunits have been demonstrated to play a role in deposition of the histone variant H3.3 onto areas of actively transcribed euchromatin in cells. The mechanism by which these subunits function together to drive histone deposition has remained poorly understood.