Trevor M Penning

Nov 4, 2024 | jbc.org | Sarah Gardner |Philadelphia Pennsylvania |Austin Vogt |Trevor M Penning

IntroductionCholesterol is a key sterol that is an essential precursor of all steroid hormones and bile acids (1-3). Cholesterol biosynthesis is tightly regulated, and homeostasis is maintained through dynamic processes of export and esterification. One of the main fates of cholesterol is primary bile acid synthesis which is the predominant mechanism for clearance of excess cholesterol (4, 5).