Autumn R. Flynn

1 month ago | digitalcommons.library.tmc.edu | Suzanne G. Mays |Emma D'Agostino |Autumn R. Flynn |Xiangsheng Huang

KeywordsAnimals, Colitis, Ligands, Mice, Phospholipids, Receptors, Cytoplasmic and Nuclear, Phospholipid, LRH-1, nuclear receptor, agonist, ulcerative colitisAbstractPhospholipids are ligands for nuclear hormone receptors (NRs) that regulate transcriptional programs relevant to normal physiology and disease. Here, we demonstrate that mimicking phospholipid-NR interactions is a robust strategy to improve agonists of liver receptor homolog-1 (LRH-1), a therapeutic target for colitis.