Avishai Barnoy

Jul 12, 2024 | biorxiv.org | Avishai Barnoy |Robert G. Parton |Michael M. Kozlov

AbstractMembrane sculpting by caveolin and accessory proteins is crucial for caveola formation. The discovery of the disc-like structure of caveolin oligomers has challenged earlier models for membrane shaping by caveolins. The flat shape of the caveolin discs apparently contradicts the large curvature of caveolar membranes these discs generate upon their predicted embedding into the cytoplasmic membrane leaflet. Here we have provided a mechanism for this phenomenon.