Robert G. Parton

Jul 12, 2024 | biorxiv.org | Avishai Barnoy |Robert G. Parton |Michael M. Kozlov

AbstractMembrane sculpting by caveolin and accessory proteins is crucial for caveola formation. The discovery of the disc-like structure of caveolin oligomers has challenged earlier models for membrane shaping by caveolins. The flat shape of the caveolin discs apparently contradicts the large curvature of caveolar membranes these discs generate upon their predicted embedding into the cytoplasmic membrane leaflet. Here we have provided a mechanism for this phenomenon.

Apr 21, 2024 | nature.com | Robert G. Parton |Justin W. Taraska

The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular scission. Until recently, dynamin was believed to regulate endocytosis through caveolae in a similar fashion. However, recent work calls for a serious reassessment of the role of dynamin in endocytosis by caveolae.

Dec 9, 2023 | lufkindailynews.com | Robert G. Parton

Reading your front-page below-the-fold article reprinted from The Texas Tribune about Mr. Stua's feud with local authorities was a little disturbing. I'm not a Lufkin native and I certainly don't know all of the details about this conflict, but on the surface at first glance, I would offer a comment. It certainly appears that Mr. Stua's more concerned with creating chaos than he is with acquiring information.

Feb 21, 2023 | nature.com | Qiang Guo |Jinbo Yuan |Jiake Xu |Robert G. Parton |Hiroshi Takayanagi |Laila Abudulai | +1 more

AbstractOsteoclasts are giant bone-digesting cells that harbor specialized lysosome-related organelles termed secretory lysosomes (SLs). SLs store cathepsin K and serve as a membrane precursor to the ruffled border, the osteoclast’s ‘resorptive apparatus’. Yet, the molecular composition and spatiotemporal organization of SLs remains incompletely understood. Here, using organelle-resolution proteomics, we identify member a2 of the solute carrier 37 family (Slc37a2) as a SL sugar transporter.

Feb 2, 2023 | rupress.org | Elin C Larsson |Björn Morén |Robert G. Parton |Kerrie-ann McMahon

Caveolae display atypical dynamics in the sense that such invaginations are stably associated with the PM over time. Yet, the mechanisms controlling the stability and fission of the caveola neck are not fully understood. Herein, we have studied the role of Dyn2 on caveola dynamics in living cells using TIRF microscopy and single particle tracking. In contrast to its role in CCV fission, we find that Dyn2 acts as a stabilizing protein, increasing the time caveolae spend at the PM.