Avishay Spitzer

Nov 1, 2023 | nature.com | Kathryn Taylor |Avishay Spitzer |Griffin G. Hartmann |Helena Zhang |Kiarash Shamardani |Minhui Su | +6 more

AbstractThe role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor1,2,3 (BDNF), and also through electrophysiologically functional neuron-to-glioma synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors4,5.

May 31, 2023 | nature.com | Michael Tyler |Rouven Hoefflin |Roi Tschernichovsky |Thomas Barrett |Michael Mints |Avishay Spitzer | +2 more

AbstractEach tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a central challenge of cancer therapeutics1. Dozens of recent studies have begun to describe ITH by single-cell RNA sequencing, but each study typically profiled only a small number of tumours and provided a narrow view of transcriptional ITH2.