Bahman Abdi-Sargezeh

1 month ago | movementdisorders.onlinelibrary.wiley.com | Pan Yao |Abhinav Sharma |Bahman Abdi-Sargezeh

Exaggerated basal ganglia beta (13–30 Hz) frequency oscillatory synchronization is a hallmark of Parkinson's disease (PD).1-3 Beta activity is not continuous, often occurring in transient packets known as bursts.4, 5 Previous work has demonstrated that beta bursts of prolonged duration and amplitude correlate with bradykinesia-rigidity components of the Unified Parkinson's Disease Rating Scale (UPDRS) score.6, 7 Furthermore, therapies such as STN deep brain stimulation (DBS) and dopaminergic...

Sep 23, 2023 | biorxiv.org | Bahman Abdi-Sargezeh |Abhinav Sharma |Philip A Starr |Sepehr Shirani

AbstractNeural activities within the beta frequency range (13-30 Hz) are not stationary, but occur in transient packets known as beta bursts. Parkinson's disease (PD) is characterized by the occurrence of beta bursts of increased duration and amplitude within the cortico-basal ganglia network. The pathophysiological importance of beta bursts is exemplified by the fact that they serve as a clinically useful feedback signal in beta amplitude triggered adaptive Deep Brain Stimulation (aDBS).