Belgin Yalçın

Jun 5, 2024 | nature.com | Belgin Yalçın |Matthew B. Pomrenze |Kiarash Shamardani |Isabelle Chau |Kathryn Taylor |Robert C. Malenka

AbstractAll drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders1,2. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated changes in myelin that can tune circuit function and influence cognitive behaviour3,4,5,6,7. Here we explore the role of myelin plasticity in dopaminergic circuitry and reward learning.