Isabelle Chau

Jun 5, 2024 | nature.com | Belgin Yalçın |Matthew B. Pomrenze |Kiarash Shamardani |Isabelle Chau |Kathryn Taylor |Robert C. Malenka

AbstractAll drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance-use disorders1,2. Another recently appreciated mechanism of neural circuit plasticity is mediated through activity-regulated changes in myelin that can tune circuit function and influence cognitive behaviour3,4,5,6,7. Here we explore the role of myelin plasticity in dopaminergic circuitry and reward learning.

Nov 1, 2023 | nature.com | Kathryn Taylor |Avishay Spitzer |Griffin G. Hartmann |Helena Zhang |Kiarash Shamardani |Minhui Su | +6 more

AbstractThe role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor1,2,3 (BDNF), and also through electrophysiologically functional neuron-to-glioma synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors4,5.