Bethan Cole

1 week ago | biorxiv.org | Michael G Ricos |Bethan Cole |Rashid Hussain |Grigori Rychkov

AbstractObjective: Hyperactive KCNT1 potassium channels, caused by gain-of-function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug-resistant seizures and in cases with infantile onset, developmental regression can follow. KCNT1-related disorders include epilepsy of infancy with migrating focal seizures and sleep related hypermotor epilepsy.

Apr 10, 2024 | cell.com | Bethan Cole |Antreas C. Kalli |Nadia Pilati |Autifony Srl

Results17Zhang Z. Rosenhouse-Dantsker A. Logothetis D.E. et al. The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels. J. Neurosci.