Michael G Ricos

1 month ago | biorxiv.org | Michael G Ricos |Bethan Cole |Rashid Hussain |Grigori Rychkov

AbstractObjective: Hyperactive KCNT1 potassium channels, caused by gain-of-function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug-resistant seizures and in cases with infantile onset, developmental regression can follow. KCNT1-related disorders include epilepsy of infancy with migrating focal seizures and sleep related hypermotor epilepsy.